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Within their new examine, the researchers made a peptide—a short chain of amino acids—referred to as SP9 to dam Syt2.
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"We developed up an image of just what the secretory equipment looked like and we knew every one of the important players," Dickey stated. "After we had an idea of how all the items worked with each other, we decided synaptotagmin-two (Syt2) was the best protein to target to block mucin secretion since it only gets activated that has a superior level of stimulation.
In lab screening, SP9 shut down the membrane fusion method by attaching to Syt2. The researchers future examined SP9 in human airway cells grown during the lab.
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